![]() To uncover a therapy that could stimulate the production of brown adipocytes, the researchers searched through Calibr's ReFRAME drug-repurposing collection- a library of 14,000 known drug compounds that have been approved by the FDA for other diseases or have been extensively tested for human safety. White adipocytes store excess energy and can eventually result in metabolic diseases like obesity, while brown adipocytes dissolve this stored energy into heat- ultimately increasing the body's energy expenditure and helping bring it back into balance. This is why certain therapeutic approaches have centered around converting white fat cells (known as adipocytes) into brown fat cells. Metabolic diseases are often caused by an imbalance in energy homeostasis- in other words, when the body takes in more energy than it expends. Gary Siuzdak, PhD, Co-Senior Author, Senior Director, Scripps Center for Metabolomics and professor of Chemistry, Molecular and Computational Biology at Scripps Research The potential of this approach is even evidenced by the FDA's recent approval of Relyvrio, the combination of two endogenous metabolites for the treatment of amyotrophic lateral sclerosis (ALS)." With our technology, we can pull out endogenous metabolites- meaning the ones that the body makes on its own- that can have the same impact as a drug with less side effects. The reason many types of molecules don't go to market is because of toxicity. Even more, it speaks to the promise of using this creative drug discovery method to identify countless other potential therapeutics. This discovery offers a potential way of addressing metabolic conditions like obesity, type 2 diabetes and cardiovascular disease. In a study from Metabolites published in August 2022, the researchers used novel drug discovery technologies to uncover a metabolite that converts white fat cells ("bad" fat) to brown fat ("good" fat) cells. Metabolites are the substances made and used during these metabolic processes- or, as a new discovery out of Scripps Research and its drug development arm, Calibr, indicates, they could also be potent molecules for treating severe diseases. ![]() "Metabolism" describes the body's chemical changes that create the necessary materials for growth and overall health.
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